Refractory anaemia terminating in a combined lymphoproliferative and myeloproliferative disorder.

Refractory anaemia terminating in a combined lymphoproliferative and myeloproliferative disorder.

We report a case of non-sideroblastic refractory anaemia which evolved to a double lymphomyeloproliferative disorder. At presentation, bone marrow appearances and peripheral blood pancytopenia without myelomonocytosis were consistent with a diagnosis of non-sideroblastic refractory anaemia. Subsequently, the patient developed pronounced myelomonocytosis and lymphocytosis with prolymphocytes. Li...

Polycythemia Vera Terminating in Refractory Ascites

A 64-year-old woman,with more than a 20 year history of polycythemia vera(PV),developed portal hypertension,myelofibrosis and extramedullary hematopoiesis accompanied by massive ascites. Portal hypertension resulted not only from infiltration of the liver sinusoids by hematopoietic cells but also from nodular regenerative hyperplasia of the liver. Wright-stained smears of ascites samples consis...

Single agent lenalidomide induces a response in refractory T-cell posttransplantation lymphoproliferative disorder.

inhibition of T-cells by dasatinib is achievable in murine models, but the doses required were higher than those required to inhibit CML models.9 Thus, if the in vivo effects of dasatinib against NK cells are similar to those against T-cells, once-daily dosing with dasatinib may result in only minor suppression of NK cell function and greater suppression might occur when dasatinib is taken at h...

Biharzial splenomegaly and refractory anaemia.

Herpesvirus hominis infection in patients with myeloproliferative and lymphoproliferative disorders.

Infection with Herpesvirus hominis, often associated with oral ulceration, was found to be more frequent in patients with myeloproliferative and lymphoproliferative disorders than in normal populations or patients with other diseases. This increased frequency was not associated with any deficiency of the humoral antibody response, suggesting a possible impairment of cell-mediated immunity. The ...